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fludrocortisone will lower the extent or result of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.cenobamate will improve the stage or influence of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Modify Therapy/Monitor Closely. Take into consideration a dose reduction of CYP2C19 substrates, as clinical